A thirty-year study led by the University of California, San Francisco found a link between polycystic ovary syndrome and later memory problems. Beginning in middle age, the condition can gradually affect the brain, leading to impairments in cognitive abilities such as memory and concentration, the researchers found. They found less white matter in the brain – an indicator of premature aging. Polycystic ovary syndrome is a condition related to the work of the endocrine system. It is characterized by the increased production of male sex hormones and the formation of ovarian cysts. It’s not certain what causes polycystic ovary syndrome, but some factors can determine your risk of developing it. Diabetes and insulin resistance are some of these factors. The rise in blood sugar levels is associated with the release of large amounts of insulin, which contributes to the higher synthesis of androgens (male sex hormones). Androgens can cause problems with ovulation in women. Emotional health can also play a role in causing the problem. Childhood trauma can lead to high levels of stress, which can cause anxiety and depression, as well as eating disorders. Changes in eating behavior before puberty can lead to obesity. Scientific studies show that early obesity is associated with an increased risk of polycystic ovaries. The hormonal imbalance associated with PCOS can lead to serious health problems. Some of them are hypertension, problems with the cardiovascular system and even cancer. Women with polycystic ovaries have trouble getting pregnant. Depending on age and symptoms, treatment for the syndrome includes dietary changes and more physical activity to address insulin resistance and high blood sugar, as well as medications to induce ovulation. Improving health would reduce the risk of premature brain aging. According to WHO data, polycystic ovary syndrome affects about 13% of women of reproductive age. References: Simmons, L. Polycystic Ovary Syndrome May Be Linked To Memory Problems In Later Years. https://www.iflscience.com/polycystic-ovary-syndrome-may-be-linked-to-memory-problems-in-later-years-72709 Huddleston, H. Associations of Polycystic Ovary Syndrome With Indicators of Brain Health at Midlife in the CARDIA Cohort. https://www.neurology.org/doi/10.1212/WNL.0000000000208104 Moore, A. Polycystic ovary syndrome: Understanding the role of the brain. https://www.sciencedirect.com/science/article/abs/pii/S0091302217300249