Dietary supplements designed to relieve premenstrual syndrome are few and contain various ingredients, the effectiveness of which in most cases has not been fully proven. Ginkgo biloba By acting on blood circulation, Ginkgo biloba leaf extracts can relieve breast pain associated with premenstrual syndrome (PMS). Omega-6 Fatty Acids Omega-6 fatty acids, particularly gamma-linolenic acid (GLA), are often included in nutritional supplements designed to relieve PMS. Borage and evening primrose oils, rich in omega-6 fatty acids, are also applied. Vitamin B6 The effectiveness of vitamin B6 in premenstrual disorders has been proven in one study and the mechanisms of action are yet to be further elucidated. Calcium Several small studies suggest that calcium intake may be effective in relieving PMS. Magnesium Several studies have shown that magnesium can affect menstrual pain and premenstrual symptoms. A recent study also suggested that taking magnesium and vitamin B6 together would be more effective than taking these two substances alone. Vitamin E Two small studies have determined the relative effectiveness of vitamin E on premenstrual symptoms. It is also important to consume foods that contain it, such as vegetable oils, oily dried fruits, seeds, egg yolk or wheat germ. Chaste tree A recent placebo-controlled study involving 175 women showed that extracts from the fruits of the Mediterranean plant Chaste tree – Vitex agnus castus, alleviated premenstrual symptoms. Chaste tree extracts are marketed in liquid form containing standardized levels of agnuside and casticin, the substances thought to be responsible for these effects. When taking chaste tree, there is a risk of interaction with certain drugs, in particular oral contraceptives. Is there a risk of taking supplements to relieve PMS? Patients who suffer from epilepsy, as well as those who take blood-thinning drugs, should not take ginkgo biloba. Taking calcium in large amounts – more than 5000 mg per day can lead to the formation of kidney stones in some patients. In addition, calcium supplements should not be taken with antibiotics from the cyclin and quinolone family, as well as preparations containing thyroid hormones. Magnesium-rich supplements should be avoided in renal failure. Like calcium, magnesium should not be taken at the same time as cyclin and quinolone antibiotics. References: https://www.vidal.fr/maladies/sexualite-contraception/troubles-regles/complements-alimentaires.html