Per- and polyfluoroalkyl substances, also known by the labels PFAS and phthalates, are two types of chemicals that disrupt the functions and hormonal balance of the endocrine system and may be linked to lower bone mineral density in adolescent males, a new study shows , published in the Journal of Clinical Endocrinology and Metabolism. Endocrine disrupting chemicals are chemicals or mixtures of chemicals that interfere with the way hormones in the body function. A number of processes in the body are related to the action of many hormones, and hormonal balance ensures the precise coordination of all life processes. Hormones are released in precisely defined quantities to cause the necessary response in the body, when the hormonal balance is disturbed, changes in the regulation of vital functions occur accordingly. Per- and polyfluoroalkyl substances – PFAS are synthetic chemicals used in non-stick cookware such as Teflon pans, as well as in clothing and food and beverage packaging. They are increasingly used in water supply. Phthalates are used in personal care products, cosmetics, as well as in food processing and children’s toys. Adolescence is an important period when the body is being built, together with the musculoskeletal system. Almost all children and adolescents are exposed to PFAS and phthalates from the environment and the products we use in our daily lives, but few studies have looked at how these chemicals may affect bone health and mineral density. The study found a link between the presence of certain PFASs and phthalates in multiple everyday products and reduced bone mineral density in adolescent boys. Because bone building occurs primarily during adolescence, disrupting this process can have lifelong consequences for bone health. Researchers analyzed urine and blood samples from 453 boys and 395 girls from the National Health and Nutrition Examination Survey – NHANES and found that higher levels of PFAS and phthalates in products that are used in everyday life may be associated with more -low bone mineral density in adolescent boys. The researchers did not find the same addictions in adolescent girls. References: https://doi.org/10.1210/clinem/dgac228