A toxin synthesized from spider venom may help with erectile dysfunction. Researchers have isolated the toxin PnTx2-6 from the venom of the Brazilian spider Phoneutria nigriventer. A spider bite is extremely painful. If the victim is male, a strong and painful erection or priapism, a condition of permanent erection, may occur. Scientists are trying to use this property of the venom to create medications to treat erectile problems, whether caused by mental or health reasons. They can also be of great benefit to older men who continue to have an active sex life. An erection is a hydrostatic effect of the entry of blood into the corpora cavernosa of the penis under nerve control – sexual stimulation causes nerve impulses to be sent to the corpora cavernosa. Under the influence of these pulses, nitric oxide (NO) is synthesized in them, which causes them to relax and fill with blood. In addition to nitric oxide, the enzyme PDE5 is also involved in the series of chemical reactions. Its blockage is the reason for the lack of erection or problems with it. NEWS_MORE_BOX The toxin extracted from the spider’s venom does not affect the PDE5 enzyme, but causes the release of nitric oxide, which leads to a direct relaxation of the smooth muscle and blood flow to the penis. The research team is of the opinion that the toxin could be a good alternative to drugs like Viagra. Further studies are needed in this direction. The experimental product is expected to be tested on volunteers with erectile problems soon. At this point, researchers have developed a synthetic version of the toxin. The next step is to find out if the compound can cause unwanted side effects. The results of the study are published in the online edition of the journal Sexual Medicine.