Obesity leads to an increased risk of prostate cancer. The risk of obesity is also hereditary and is passed on through the paternal line. This was found in a new scientific study presented in the journal Nutrients. It describes how obesity increases the risk of prostate cancer and shows that fat accumulation directly leads to processes that increase the risk of cancer. The accumulation of fat affects all systems in the body, but mostly affects the adipose tissue itself. The excessive amount of fat in fat depots leads to hypertrophy and hyperplasia of fat cells � processes that stimulate additional fat deposition, as well as an increase in the number of fat cells. Hyperplasia can block blood flow to adipose tissue, potentially leading to necrosis of fat cells, as well as initiation of inflammatory processes. These processes may be systemic and lead to the rupture of fat cells and their eventual cell death. It is the factors that are responsible for the inflammation in the fat cells that are linked to the formation of cancer. The male prostate is considered in three parts – peripheral, central and transitional. Peripheral is the area where over 70% of all prostate cancer cases occur. But in a large part of all the cells of the organ, there is an androgen receptor, which allows the body to correctly perceive androgens – steroid hormones that are responsible for the development of the male reproductive system (testosterone is one of the main androgens). Damage to the androgen receptor can lead to the development of prostate cancer. An imbalance in cholesterol levels is a common cause of this type of cancer. New research describes how obesity-induced inflammation affects testosterone levels. Separately, it was found that there are factors in the genetic composition of the man’s body that predispose to obesity. These factors are inherited, and according to the researchers, this paternal risk of obesity is most pronounced in daughters, not sons. Obesity is the most common and one of the most dangerous metabolic diseases worldwide. According to data from the WHO, more than 1.9 billion people worldwide suffer from obesity. References: Santos-Pereira, M. (2023, November 21) Decoding the Influence of Obesity on Prostate Cancer and Its Transgenerational Impact. https://www.mdpi.com/2072-6643/15/23/4858