Penile malignancies are a rare type of tumor. In most cases, they affect the skin of the penis or foreskin. For some pre-cancers, there is a clear correlation for their association with the development of penile cancer. These are primarily the lesions associated with HPV infection, such as Queyrat’s erythroplasia, Bowen’s disease, and bonevoid papulosis. Precancers in up to 30% of cases progress to the development of malignant disease of the genitals in men. In general, malignant tumors of the penis can be divided into epithelial tumors, mesenchymal tumors – sarcomas and other tumors that primarily involve the penis. The most common variant found is from the group of epithelial tumors – squamous cell carcinoma – 95% of all malignant neoplasms that involve the penis. Less common are verrucous and basal cell carcinomas of the penis. Verrucous carcinoma is a slow-growing variant of squamous cell carcinoma with a low tendency to metastasize. The group of mesenchymal tumors includes leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma and angiosarcoma. Leiomyosarcoma and fibromyosarcoma are divided into superficial and deep depending on whether they originate from the musculature of the glans or the corpora cavernosa of the penis. Angiosarcoma is also called Kaposi’s sarcoma and is a malignant growth of capillaries in the skin and internal organs. Kaposi’s sarcoma is the most common tumor disease in AIDS patients and is found in up to 3% of patients. Secondary (metastatic) penile tumors are extremely rare and isolated cases have been reported. Early forms of penile carcinoma are usually asymptomatic. The patient feels slight irritation, itching and redness in the area of ??the glans or foreskin of the penis. Gradually, patients begin to notice flat areas represented by redness or nodular formations. Rarely, erosive-ulcerative lesions develop. In summary, according to the frequency of detection of complaints, in 40% of cases, a lump or wart is found mainly in the area of ??the glans or the front of the penis. Erosion or ulcer (ulcer) also occurs in up to 40% of cases. Pain and itching are a less common accompanying complaint – 12% of cases. Secretion from the foreskin is seen in up to 12%, and edema and enlarged local lymph nodes are an extremely rare finding. Late complications that may occur if the neoplasm is not detected in time include hardening and swelling of the entire penis, urinary disturbances and lymphedema of the lower extremities as a result of significantly enlarged regional lymph nodes. The diagnosis is made by examination and subsequent biopsy of the affected area, and histological examination serves to differentiate and stage carcinoma. Treatment of penile carcinoma can be surgical or laser and should be tailored to the extent of the carcinoma, the patient’s age and co-morbidities.The main principle of the surgical intervention is a wide excision of the tumor in a healthy way by partial or total penectomy. Laser treatment is an option for organ-preserving therapy. However, a disadvantage of its application is that it is not possible to accurately determine the depth of carcinoma growth, which may be a prerequisite for incomplete excision of the affected tissue. The presence of metastases in most cases complicates the course of the disease and requires additional treatment. This determines the need for a precise assessment and search for metastases at the time of diagnosis. After surgical or laser treatment of patients, the latter are subject to follow-up every 6 months with a view to early detection of disease recurrence and timely treatment. References: 1. Urology, Prof. P. Panchev; 2. https://www.cancer.org/cancer/types/penile-cancer/about/what-is-penile-cancer.html