Genetic predisposition to prostate cancer does not determine the outcome of the disease, a study by Brigham and Women’s Hospital researchers found. According to their data, men who lead a healthier lifestyle have an approximately 50% lower risk of fatal disease. The team of specialists used data from 12,000 men whose blood samples were taken in the 1980s and 1990s. They also received detailed information on factors related to their lifestyle during follow-up. Participants’ genetic risk was calculated retrospectively. The aim of their analysis is to check whether the genome of these men is decisive for the outcome of the disease. Specialists observe how the lifestyle of these people affects the progression of the tumor. The authors assessed healthy lifestyles based on a previously published classification used in prostate carcinoma. It takes into account the body mass index – in order to define the weight as healthy, it must be below 30. The intensity of their physical activity, the absence of smoking and the presence of a healthy diet is determined. For a healthy diet, experts accept one rich in tomatoes and fish, in which the intake of processed meat is low. The team assessed the overall risk of developing prostate cancer, regardless of the stage of the disease. They also take into account the risk of mortality and the occurrence of multiple metastases. In conclusion, the researchers found that among men at high genetic risk, those who followed a healthy lifestyle had a 45% lower risk of mortality from prostate cancer compared to those who did not follow a healthy lifestyle. of life. Men with a high genetic risk and an unhealthy lifestyle have the highest lifetime risk of fatal disease at 5%, while men with a high genetic risk following a healthy diet have about 2%. Information from the study was published in the journal European Urology. References: https://www.sciencedirect.com/science/article/pii/S0302283822023429?via%3Dihub