Exercise could reduce weight in obese women in whom diets fail. This information was obtained after conducting a randomized clinical trial in which overweight women were included. Obesity is a common problem that some people manage to solve by following a certain diet. However, for many others, weight loss is difficult to achieve. According to the research conducted, physical training could reduce the amount of body fat as well as improve the bioenergetic function of skeletal muscles in people whose phenotype is resistant to different diets. In them, more fat is usually found in the lower part of the body. Many of the implemented individually tailored diets lead to the corresponding predicted results. However, people’s bodies may react differently. According to experts, this could be due to the respective differences in the muscle composition of each person. The study evaluated the results of constant training in overweight women, which, when following various diets in the past, did not lead to significant results. From more than 5,000 patient records, the researchers looked at 228 files to track changes in each person’s weight. The study participants are divided into subgroups. One included 20 obese women who were resistant to different diets and another with those who were sensitive to diets. During the study, they followed a 6-week training program that included aerobic and resistance exercise. The results found that diet-sensitive women had lower baseline adiposity, higher fasting insulin and triglycerides, and more positive criteria for metabolic syndrome. Conversely, in women in whom dieting was ineffective or had little effect, physical activity was found to improve body composition, skeletal muscle mitochondrial content, and metabolism. Further analysis of muscle composition revealed significant differences, including lower serine-linked sphingolipid synthesis in non-dieting women. Information about the study is published online in the journal EBioMedicine. References: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00373-5/fulltext