Yaws disease is an infectious disease caused by the pale spirochete Treponema pallidum subspecies pertenue. It is for this reason that in many medical textbooks the disease is called pertenyu. It is still found under the names thymosis, tropical yams, multiple tropical papilloma, parangi, bubba and yams. The dangerous bacteria was brought from Africa. It is also known to cause syphilis in humans in its primary form, Treponema pallidum. The infection affects the skin, bones and joints in humans and animals. It begins its clinical manifestation with a round formation on the skin, which undergoes tissue decay. In some cases, an ulcer can develop in the core of the wound surface, which is a prerequisite for the penetration of many other bacteria into the systemic circulation and, accordingly, the appearance of many other infectious diseases, including the spontaneous development of sepsis. The size of the wound is usually between 2 and 5 centimeters in diameter. This specific skin infection usually heals within three to six months. After years, however, the disease may recur. Then usually the bones and joints in the body are already affected, becoming easily brittle and the joints weak. Recurrence of skin wounds is also possible. The skin on the palms of the hands and feet can become rough and suddenly start to crack, forming large and bleeding skin ulcers. The disease is spread most often by direct contact of the wound surface with the skin of a healthy person. Sexual transmissibility for this particular disease is possible but less commonly diagnosed in humans. Most often, the disease affects children, who spread it very easily among themselves during mutual play or during prolonged stay in a closed space – nursery, kindergarten, school, etc. What are the clinical stages of the disease? During 90 days, but in more frequent cases it is for less than a month, from the activity of the infection, a pathological papular growth appears on the surface of the skin, which is characterized by the fact that it is painless. It gradually enlarges and begins to give some specific symptoms – such as irritation, itching or simply a “feeling” of something foreign. This is usually the first stage of the disease, which lasts for six months. NEWS_MORE_BOX The second stage of the disease is registered after a few months or years later, and the clinical picture is particularly characteristic. Mass deposition and growth of such skin wounds begins, which spread throughout the body. Extensive lesions form on the palms and soles with desquamation. Lesions in the secondary stage have a very high vulnerability factor, which makes them even more dangerous from seriously infecting the entire organism with foreign microorganisms. They usually heal on their own within six months. During the third stage of the disease, only 10% of people managed to save themselves without taking medicines.Typically, at this stage, patients develop massive skin, soft tissue, bone and joint destructive changes that disrupt their overall structure and disable them. The bones of the nose are most often affected and this often leads to the development of mutilating nasopharyngitis or the disease gangosis. The basic laboratory methods are considered in the diagnostic plan. The characteristic here, however, is that with the standard test for antibodies in a peripheral blood sample, the test has no authoritative value, because antibodies are circulating in already treated and controlled patients, and in those with active infection at the time of the test. At the moment, it is believed that PCR – polymerase chain reaction and TPHA give the most reliable result in case of momentary infection activity. According to specialists in infectious diseases, the gold standard in the treatment of this type of infection and to this day remains the intramuscular application of a penicillin antibiotic. Erythromycin and tetracycline taken in the form of tablets are also celebrated with good results. A study by English specialists found that the application of azithromycin was the highest. According to the study, only 0.8% of all patients tested did not achieve radical success in their treatment.