Neoplasias of the prostate gland require different therapeutic approaches depending on the stage of the disease. In clinical practice, a standard classification of tumors according to their spread is adopted. Determining whether a tumor has metastasized or not and classifying it into the appropriate category is called staging. Correct staging is a key diagnostic point, as it is crucial for adequate treatment and successful disease control. Staging requires one or more of the following tests: Radinuclide bone scan – in which a small amount of radioactive material is injected into a vein from where it reaches the bones. The material can be detected with a scanner. The test is used to detect rapidly dividing tumor cells in the bones. Nuclear magnetic resonance – in this procedure, with the help of a magnet and a computer, highly informative images are obtained from the inside of the body. Pelvic lymphadenectomy: this is the surgical removal of one or more lymph nodes from the pelvis, after which the tissue is examined under a microscope for the presence of tumor cells. Computed tomography – with the help of X-rays, a series of pictures is taken of the inside of the body from different angles. In some cases, a radiopaque material is injected to more clearly visualize the examined tissue. Seminal vesicle biopsy – fluid is taken from the seminal vesicles. These are glands along the course of the male reproductive system that secrete part of the seminal fluid. The sample is examined under a microscope to check for the presence of cancer cells. NEWS_MORE_BOX Staging also takes into account the results of the measurement of prostate specific antigen and the biopsy of the original tumor. During the biopsy of the tumor, the so-called Gleason score, which can range from 2 to 10 and is indicative of the likelihood that the tumor will metastasize. A low Gleason score means that the tumor tissue is close to normal prostate tissue and is unlikely to spread to other organs and tissues, while a high score indicates that the tumor tissue is highly degenerated and more likely to spread. There are three different ways for tumors to spread: tissue – the cancer invades the surrounding healthy tissue; through the lymphatic system – tumor cells fall into the lymphatic vessels, through which they reach other parts of the body; through the blood – tumor cells enter the veins or capillaries and spread. When tumor cells reach a new location and begin to grow there, a secondary tumor is formed, called a metastasis. The secondary tumor is of the same type as the primary. For example, if prostate cancer metastasizes to bone, it is secondary prostate cancer, not bone cancer. Prostate cancer is divided into four main stages: Stage I Tumor cells are localized only in the prostate. The tumor: is found in a needle biopsy, or there is a small amount of malignant tissue that was found during surgery for other reasons.Prostate specific antigen level is below 10. Gleason score is 6 or below. the tumor is found in only half or less of a single prostate lobe. Prostate specific antigen level is below 10. Gleason score is 6 or below. the tumor cannot be palpated (felt through the fingers, felt) during a rectal examination and is inconspicuous during imaging. The tumor is found in half or less of a single prostate lobe, and the prostate-specific antigen level and Gleason score are unknown.