Depending on the stage of the neoplasia, treatment is usually carried out by one of the following methods or therapeutic combinations. Stage I Radical prostatectomy, usually with pelvic lymphadenectomy – removal of pelvic lymph nodes. After removal of the prostate, radiation therapy may also be performed. At this stage, the prostate can be removed without affecting the surrounding nerves, which excludes complications such as incontinence and erectile dysfunction. Treatment with an external source. Internal source radiation therapy. Stage II Radical prostatectomy, usually with pelvic lymphadenectomy. After removal of the prostate, radiation therapy may also be performed. At this stage, in some cases, the prostate can be removed without affecting the surrounding nerves, which excludes complications such as incontinence and erectile dysfunction. Treatment with an external source. Internal source radiation therapy. Stage III Radiation therapy with an external source with or without hormone therapy. Hormonal therapy. Radical prostatectomy, with or without pelvic lymphadenectomy. After removal of the prostate, radiation therapy may also be performed. Radiation therapy, hormone therapy, transurethral prostate resection, as palliative therapy to relieve symptoms. Stage IV Hormonal therapy. Radiation therapy with an external source, with or without chorionic therapy. Radiation therapy or transurethral prostate resection as palliative therapy to relieve symptoms. Treatment of relapses Radiation therapy. Prostatectomy, in patients initially treated with radiation therapy. Hormonal therapy. Immunotherapy in patients receiving hormone therapy. NEWS_MORE_BOX Chemotherapy. Pain relievers, external or internal radiation therapy, palliative therapy to relieve bone pain. In certain cases, the treating clinician may deem it most appropriate to refrain from active treatment for a period, during which time the tumor is only monitored at short intervals. If regular tests show a change in the patient’s condition, the doctor may decide to switch to one or the other treatment. Clinical trials are also being conducted on various drugs indicated for prostate cancer at one stage or another. In our country, all studies are overseen by the Medicines Executive Agency, from where information can be obtained about ongoing studies, as well as studies that are to be conducted in the near future.