Gender-based medicine has been of interest to the medical community since the 1990s, with a particular interest in health disparities between men and women. Globally, male life expectancy is four or five years shorter than female life expectancy. Men have been found to have a higher mortality rate than women from the embryonic stage to old age. This difference in mortality is usually due to lifestyle-related health problems in young men, as well as the relatively high incidence of cardiovascular disease and malignancy after middle age. Based on some studies, there are differences between men and women in about 15 major causes of death. According to some studies, there is a higher death rate among men in 12 diseases, and particularly large differences are also found in cardiovascular diseases, hypertension, diabetes and cancer. The biological basis for these differences may be rooted in greater oxidative stress (a condition in which there is a lack of antioxidants), X-chromosome compensation (when there is a change in a gene on the male X-chromosome, there is no other copy of that gene, which to compensate for the altered because men have only one X chromosome), differences in the length of telomeres (the ends of chromosomes that are associated with the rate of aging and life span), the more perfect function of the immune system in women and the protective effect of estrogen against various diseases in women. Determining the reasons for the difference in life expectancy between men and women is the first step towards improving men’s health, and such research must account for differences that cannot be explained by genetic factors alone. Biological differences, such as hormonal differences and environmental factors, as well as men’s occupation of more life-threatening occupations, must also be taken into account. In addition, men have specific lifestyle characteristics that predispose to higher mortality, such as a higher-risk lifestyle, men’s tendency to resist changing unhealthy behaviors, and less likelihood of seeking medical treatment. help. The goal of the analyzes is to clarify these factors and improve them to protect men’s health.